University of California San Diego

In December 2017, we entered into a research collaboration with University of California San Diego led by Dan S. Kaufman, M.D., Ph.D., Professor of Medicine, Division of Regenerative Medicine, and Director of Cell Therapy at UCSD. Under the collaboration, we evaluated chimeric antigen receptor (CAR) constructs containing transmembrane and co-stimulatory domains optimized for antigen-specific activation and effector function in NK cells. The specific goals of the collaboration are to develop off-the-shelf, CAR-targeted NK cell cancer immunotherapies using clonal engineered master pluripotent cell lines.